Formulation and development of hesperidin loaded solid lipid nanoparticles for diabetes

Praveen Kumar Gaur1, *, Himanshu Pal1, Dinesh Puri1, Nitin Kumar2 , Sadish Kumar Shanmugam3

1Department of Pharmaceutics, I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India

2Department of Pharmacognosy , I.T.S. College of Pharmacy, Muradnagar, Ghaziabad,Uttar Pradesh, India

3Department of Pharmaceutical Chemistry , I.T.S. College of Pharmacy, Muradnagar, Ghaziabad,Uttar Pradesh, India

*corresponding author e-mail |Scopus ID 35223173000

Biointerface Research in Applied Chemistry, Volume 10, Issue 1, 2020, 4728 – 4733,


Most of the research on Diabetes has been focused on synthetic compound however the disease burden of Diabetes has not been reduced, natural chemistry has provided various safer options in different disease areas. Hesperidin (bioflavonoid) has shown good promise in anti-diabetes efficacy however its bioavailability is low. In this work, SLN of Hesperidin wasprepared, physiochemically evaluated and tested for anti-diabetic potential. Various drug- lipid ratio were tested along with other formulation parameter for fabrication of formulation and optimization. The optimized formulation has been shownuniform particle size with negative surface charge with more than 90% entrapment efficiency and 91.45% drug release. The formulation exhibited Korsmeyer-Peppas release kinetic. The optimize formulation showed 21 % increase in anti-diabetes activity of hesperidin.

Keywords: Solid Lipid Nanoparticles; Hesperidin; Diabetes; Bioavailability.