Can oxidative stress markers help define stroke prognosis?

Maria Paula Ribeiro Barbosa ¹, Luan dos Santos Mendes ¹, Daisy de Araujo Vilela ², Mirella Veras 3, José Carlos Tatmatsu Rocha ¹,4

¹Medicine School, Physiotherapy Department, Federal University of Ceará, Fortaleza, Ceará, Brazil

²Physiotherapy Department, Federal University of Goiás, Jataí, Goiás, Brazil

3Centre de recherche interdisciplinaire en réadaptation du Montréal métropolitain (CRIR), Canada

4Postgraduate Program in Biomedical Engineering, University of Brasilia, Brasilia, Distrito Federal, Brazil

*corresponding author e-mail address: | Scopus ID 57191255574

Biointerface Research in Applied Chemistry, Volume 10, Issue 1, 2020, 4864 – 4868,


Objective: To identify which oxidative stress markers can influence early stroke prognosis. Methodology: This is a systematic review carried out in two databases, PubMed and Web of Science, from November to December 2018. Two blinded, independent researchers probed the databases and gleaned descriptors indexed on both sites. “Markers”, “oxidative stress” AND “stroke” were the terms singled out for this study. The inclusion criteria were: the articles needed to have been published in English from 2013 to 2018, as well as include descriptors either in the title or in the abstract, and involve clinical trials with samples composed of stroke survivors. The exclusion criteria were: research involving animal experimentation; duplicate publications; articles without a clear methodology; articles that chiefly addressed any disease other than stroke, and those that were not available in full. Results: This review identified TBARS, catalase, nitric oxide (NO), Thiois, C-reactive protein and SOD as the most recurrent oxidative regulation markers in stroke survivors. These findings may direct new research toward obtaining early prognoses, and therefore enable more accurate decision-making. thus minimizing the costs and time related to the patient rehabilitation process.

Keywords: Markers, Oxidative Stress, Stroke, Cerebrovascular Accident, Biomarkers.