Magnesium chloride impairs physio-biochemical and neurochemical responses in Cirrhinusmrigala (Hamilton, 1822) upon short term exposure

Sharath Chandra S. P. 1,*, Sandya Sukumaran 2

1Department of Biochemistry, Government Science College, Hassan, Karnataka, India

2Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, India

*corresponding author e-mail address: | Scopus ID 57194067027

Biointerface Research in Applied Chemistry, Volume 10, Issue 1, 2020, 4934 – 4938,


The present investigation was performed to establish the biochemical and physiological impact of Magnesium chloride (MgCl2) on fresh water fish Cirrhinusmrigala. In this direction we have evaluated the biochemical and neurochemical impact of MgCl2 on C. mrigala, a fresh water fish extensively consumed. Biochemical, neurochemical and physiological alterations were analyzed in the present study and LC50 of MgCl2 was found to be 192 ppm, observed for 24h. Further 1/10th of the LC50 concentration of MgCl2 (19.2 ppm) was chosen for short term examination at 96 h. The results demonstrate elevation in levels of serum lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT) levels compared to control groups. Studies revealed variations in oxidative stress markers with significant reduction in the serum super oxide dismutase (SOD) and catalase (CAT) levels, and increase in malondialdehyde (MDA). The study showed an increase in brain glutamate levels reflecting possible brain tissue damage.  The above study highlights the potential biochemical impact of MgCl2 on fresh water fish.

Keywords: Biochemical, Cirrhinusmrigala, Magnesium chloride, Neurotransmitter, Physiology.

Abreviations:ALT: Alanine transaminase, AST: Aspartate transaminase, CAT: Catalase, LDH: Lactate dehydrogenase, MDA: malondialdehyde, ROS: Reactive oxygen species, SOD: Superoxide dismutase.